Yeah, I'm pretty sure the hotkeys were messing with that. When I use spells manually (select a target, then double click the spell from the spell inventory) they work fine. I'm not sure what was going on there, but it would somehow reference spell indexes incorrectly. So I did away with it, because I ran out of GUI room also.
Also, not sure if I mentioned this. Added a nicer setup for mouse-over of items. Showing a bit more detail, such as efficacy of all stats, price, and type of item. The mouse over works both in your inventory and with your currently equipped items.